Cancer Research
Pancreatic Cancer

Pancreatic Cancer and Diabetes

Because excess risk for pancreatic cancer exists equally in all patients diagnosed with diabetes, it has recently been suggested that pancreatic cancer might be at least a contributing factor or rather an early manifestation of pancreatic cancer in its advanced stage. It has also been noted that younger patients diagnosed with diabetes are more likely to die from pancreatic cancer than older patients. These observations have prompted the need for research into the causes of this disparity in mortality rates and suggested new strategies for the prevention and treatment of pancreatic cancer in patients with diabetes.

Genetic History

The study looked for susceptibility factors for pancreatic cancer by analyzing twin studies. Twin studies are basically studies of two individuals who share a common genetic history, in this case, the presence of the pancreatic tumor gene mutation CDH8. The mutation occurs on the exonuclease gene, which is involved in establishing regulatory programs in cells and organisms. Gene therapy was an effective treatment for genetic defects in the past, but it has also been used to treat pancreatic carcinoma due to its effectiveness against these genetic mutations. Genetic mutations can also pass down through the generations, which makes them extremely high-risk factors.

Researchers have speculated that the higher incidence of pancreatic cancer may occur due to the fact that people with the mutation are at a higher risk of developing other life threatening diseases such as cardiovascular disease, Alzheimer’s disease, and Type II diabetes. The increased risk factors were also seen in obese people, those with chronic pancreatic dysfunction, and in women who have a family history of the disease. There are increased risk factors for patients with polycystic Ovarian Syndrome and insulin resistant men. Research suggests that people who are more susceptible to asbestos exposure may be at greater risk. Other factors, such as smoking and alcohol consumption, may also play a role in the development this disease. These studies cannot prove that asbestos exposure alone causes the disease.

Reducing Risk Factors

There are many things you can do to help this type of cancer if you believe you have been diagnosed. Patients with pancreatic cancer must avoid caffeine and alcohol, as well red meat, fish and white sugar. You should inform your doctor about all foods you eat. If you are diagnosed with the tumor, you should immediately stop ingesting all forms of these foods in order to give your body enough time to recover from the diagnosis. To provide your body with the necessary vitamins and minerals, you should stop taking nicotine-containing medications and start taking daily nutritional supplements.

There are several factors that affect the chances of getting pancreatic cancer, such as your race, age, weight, gender, and family history. Being a man with this condition is related to an increased risk of getting this disease. Women of all ages who were women before they were diagnosed with the tumor tend to live longer than women who were men. The average survival rate after being diagnosed is around 95%.

Increased Risk Factor for Pancreatic Cancers

Other factors that are linked to an increased risk factor for pancreatic cancers include obesity, chronic pancreatitis, and diabetes. People who consume more than eighty alcoholic beverages per week are at a high risk for developing this condition. Patients with diabetes have also been shown that alcohol consumption increases the risk of developing pancreatic cancer. There is a positive association between obesity and chronic, severe pancreatitis. Chronic pancreatitis is more common in diabetics. This can be treated with antidiabetic medication.

There are two broad genes that have been identified as having an effect on the risk of pancreatic cancer in humans. Although they are not directly related to any diseases, these genes have an effect on how much glucose is produced by the liver. When the liver does not produce enough glucose, your blood glucose level will be too high. This condition can lead to pancreatic cancer or the development of other serious diseases such as type II diabetes. The two genes that have been identified as having an effect on the production of glucose are brca1 and brca2.

Another condition directly related to pancreatic carcinoma is jaundice. It is caused by a lack of bile. Bile is necessary for the proper digestion of fat. If you suffer from jaundice, there may not be enough bile in your body so your body produces too much bilirubin. Pancreatic cancer is indicated by a high level of bilirubin.

Next Steps

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